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White Paper: Cannabinoids for the prevention of aging

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Written by Alexia BlakeHead of Research & Product Development

The desire to maintain healthy and youthful-looking skin is a commonly shared goal amongst skincare consumers that spans many geographical and generational divides. In a culture shaped by social media and following the start of a new decade defined by the ongoing and inevitable long-lasting effects of the COVID-19 pandemic, consumers are more aware than ever before of their physical, mental and emotional well-being. With skin being our largest organ and often a reflection of inner turmoil caused by stress, lack of sleep, and lifestyle factors related to sun exposure, diet, and alcohol consumption, it does not come as a surprise that the anti-aging products market is projected to reach US$47.8 billion by 2027.

Until now, this bourgeoning segment has been dominated by active ingredients like vitamin C, retinoids, and alpha- and beta-hydroxy acids. Yet despite their proven efficacy for addressing signs of aging skin, these ingredients are notorious for causing irritation and photosensitivity, particularly in the case of retinoids and exfoliating acids. For the 50-60% of men and 60-70% of women who report some degree of sensitive skin, these side effects can hinder the long-term and routine use of these ingredients and, in the short-term lead, to a frustrating trial-and-error experiment marked by red, dry and peeling skin as the fair price for participating in the seemingly never ending search for the right product, right concentration, and right routine that encompasses all of these ingredients (and then some) as suggested by today’s dermatologists, beauty gurus, celebrities and influencers. The quest for healthy and youthful-looking skin should not be this complicated or painful.

Herein lies the exciting promise of cannabinoids as active skincare ingredients. Generally speaking, the vast majority of cannabinoid research conducted to date has focused on cannabidiol (CBD) and delta- 9-tetrahydrocannabinol (THC) as these are the most abundant and readily available cannabinoids produced by the plant species Cannabis Sativa L. However, the recent adoption of well-established manufacturing methods, namely biosynthesis and chemical synthesis, have enabled the commercial availability of other cannabinoids like Cannabigerol (CBG), ushering in a new era of cannabinoid research and development while simultaneously creating a reliable supply chain defined by high-purity, consistent, sustainable and compliant ingredients.

Recognizing this opportunity and as part of our promise to offer products that are science-backed and efficacy led, Cellular Goods has engaged in meaningful research to understand how these lab-made cannabinoids can benefit skin. First and foremost, our findings indicate that CBG, CBD and their blends can inhibit inflammation and lipid peroxidation caused by UVB radiation, both of which are well- established factors contributing to aging and disease. By testing on cultured human tissues and at commercially relevant cannabinoid concentrations, these results provide material insights into the modality and utility of cannabinoids to maintain skin health and prevent signs of aging caused by UV exposure and inflammation.

Secondly, these results complement recent findings published by Willow Biosciences Inc., a leading biotechnology company that manufactures pure, consistent and sustainable cannabinoids via yeast biosynthesis. Their research sheds further light on the considerable anti-inflammatory and antioxidant activity of CBG and CBD that, when taken together with Cellular Goods’ findings, reveal these cannabinoids can counteract the well-established aging effects of UV exposure (also known as photoaging) and inflammation (recently coined “inflammaging”), equally and in some cases more effectively than vitamin C. The tolerability and combined anti-inflammatory and antioxidant properties of these cannabinoids make them compelling ingredients that provide multiple mechanisms against extrinsic aging factors, thereby qualifying them as novel ingredients with immense potential for skincare solutions designed to prevent signs of aging.

Cellular Goods has incorporated these novel findings into a range of cannabinoid-based skincare products, which have been dermatologically tested and shown to be suitable for sensitive skin. The exclusive use of lab-made cannabinoids guarantees batch consistency and unparalleled purity, with all products undergoing rigorous testing during stability, manufacturing, and clinical evaluations. As the first manufacturer of CBG-powered skincare in the UK, we are delighted to offer consumers science- backed products designed to prevent signs of aging without the worrying side-effects common to the current industry-standard ingredients. CBG and CBD are ushering in a new skincare revolution from which we all stand to benefit.

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